Impact of vaginal ascorbic acid on abnormal vaginal microflora | Semantic Scholar (2024)

Treatment of recurrent BV during pregnancy with recombinant human interferon alfa-2b, aimed at boosting the nonspecific vaginal immunity helps reduce the incidence of recurring BV.

This review will consider studies that compare treatment regimens of intravaginal vitamin C (ascorbic acid) with placebo and the following outcome measures: cure rate defined by the presence and/or absence of Amsel criteria or Nugent criteria, and secondary outcomes and adverse events.

The aim of this study was to determine the susceptibility of germs and factors associated with cervico-vaginal infections in women of childbearing age at the Mother and Child University Hospital in Ndjamena, and to health education of the population regarding these infections.

This review aims to provide a comprehensive and up to date outline of the landscape of ongoing and potential treatment and prevention strategies for BV.

This review provides a quick synopsis of the currently approved and available antibiotics for BV treatment while presenting an overview of novel strategies that are being explored for the treatment of this disorder, with special focus on natural compounds that are able to overcome biofilm-associated antibiotic resistance.

In search of new therapeutic actions to cure, prevent or delay recurrences of BV, PubMed and web of science were searched for papers with decent study layout, proper statistics, and the following keywords were used: bacterial vaginosis and treatment or management or therapy or prophylaxis or prevention.

Women supplemented with vitamin C alone or in combination with other supplements compared with placebo or no control were at decreased risk of having a placental abruption and vitamin C supplementation alone was associated with a reduced risk of preterm PROM.

The hydroethanolic extracts of OCimum basilicum and Ocimum gratissimum have antibacterial, antioxidant, and anti-inflammatory properties, justifying their anti- inflammatory properties.

The results support an effective and safe use of silicon-coated Vit.

The efficacy of vaginal tablets containing 50 mg of a lyophilisate of viable, H2O2-producing Lactobacillus acidophilus and 0.03 mg estriol for the treatment of bacterial vaginosis (BV) was tested in a multicentric, randomised, placebo-controlled clinical trial with parallel-group design.

The study results confirm that the vaginal application of vitamin C has an effective and long-lasting vaginal pH-lowering effect and acceptability and tolerability were rated as very good/good in most cases.

Oral clindamycin eradicated abnormal flora in 90% of treated pregnant women and maintained a normal flora in two thirds of women throughout pregnancy.

Vaginal acidification with an acetic acid-based vaginal gel formulated to pH 3.9 to 4.1 was ineffective therapy for bacterial vaginosis.

The role that vaginal lactobacilli may play in control of the vaginal microflora and maintenance of the normal state is emphasized and the limitations of the methodology for such investigations must be considered.

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